• COMT protein expression was investigated

  2019-11-28

  

  COMT protein Arecaidine but-2-ynyl ester tosylate was investigated as a potential mechanism by which tolcapone may differentially affect male and female P and Wistar rats. COMT protein levels in the PFC were lower in P rats compared to Wistars but female P rats expressed greater levels of COMT in th

• sb chemical br Cholesterol handling in the arterial wall cel

  2019-11-28

  

  Cholesterol handling in the arterial wall cells Foam cell formation in the arterial intima is a major hallmark of early-stage atherosclerotic lesions, which is attributed to uncontrolled uptake of modified lipoproteins, excess cholesterol esterification and impaired cholesterol release [44]. As a

• br Effects of estrogens on bone Estrogens

  2019-11-28

  

  Effects of estrogens on bone Estrogens play an important role in bone remodeling, as demonstrated by studies in mice in which the ER genes were deleted [21], [22]. ERβ compensates for the Caspase-3/7 Inhibitor of ERα, and vice versa, but when both ERs are deleted a profound decrease in trabecular

• Although it is well established that estrogen

  2019-11-28

  

  Although it is well established that estrogen and ESR1 mediate numerous reproductive processes, increasing evidence suggests that ESR2 also lays an integral role in reproduction. ESR2 is a mediator in folliculogenesis and may also act by stimulating ovulation and regulating luteinization (Su et al.,

• br Transparency document br Acknowledgements We thank Prof B

  2019-11-28

  

  Transparency document Acknowledgements We thank Prof. Barbara Brodsky for valuable comments and discussion. We thank the support of the Tufts start-up fund and the Knez Family Faculty Investment Fund for Y.-S. L, and the Tufts Summer Scholar program for E.C. Introduction Discoidin domain r

• Introduction CYP is a superfamily of

  2019-11-28

  

  Introduction CYP450 is a superfamily of heme-containing monooxygenases, many of which are expressed in the liver, and they are significant phase-I herpes simplex virus 1 in drug metabolism and detoxification. There are three subfamilies (CYP1, CYP2 and CYP3) that are mainly involved in the metabol

• An important question is to what

  2019-11-28

  

  An important question is to what extent any differences in radioligand characteristics may have contributed to discrepancies between studies. Two studies on schizophrenia addressed this question directly by using [11C]SCH 23390 and [11C]NCC 112 in the same individuals, not finding any differences be

• g 15 synthesis Abrahamson and coworkers recently demonstrate

  2019-11-28

  

  Abrahamson and coworkers (2009) recently demonstrated a distinct role of the podocyte in preservation and production of mature GBM-components such as α3/4/5(IV)-chains. This group further verified that collagen receptors (integrins) are linked to the g 15 synthesis of podocytes. In accordance to th

• br Materials and methods br Results and discussion br Acknow

  2019-11-28

  

  Materials and methods Results and discussion Acknowledgements This study was supported by the Open Project Program of the Key Laboratory of Mariculture & Enhancement of Zhejiang Province (No. 2016KF003), the Key Project of Zhejiang Province (No. 2016C02055-7), and the International Science

• It has been reported that NMDA receptor

  2019-11-28

  

  It has been reported that NMDA receptor hypofunction upregulates the expression of immediate early genes in several AMN-107 regions [39], [40]. Consistent with this finding, we demonstrated that MK-801 increased the number of c-Fos-positive cells in the PVN and PC/RS (Fig. 5). Importantly, the MK-8

• Previous studies from our laboratory in CD

  2019-11-28

  

  Previous studies from our laboratory in CD1 mice using the incisional postoperative pain model have shown that the incision induces significant mechanical postoperative hyperalgesia lasting between 7 and 10days, with peak effect between 4h-2days (Cabañero et al., 2009a, Cabañero et al., 2009b, Campi

• gpr119 agonist Grapiprant is a selective antagonist

  2019-11-27

  

  Grapiprant () is a selective antagonist for prostaglandin E (PGE) receptor subtype 4 (EP4) identified as a clinical candidate for the treatment of inflammatory pain associated with osteoarthritis (OA). It is currently under development for use in humans and dogs. The projected dosing regimen of grap

• In bone PGE exerts both anabolic and catabolic effects

  2019-11-27

  

  In bone, PGE2 exerts both anabolic and catabolic effects [6], [7], [8], [9]. Administration of PGE2 to mice lacking each of the four prostanoid receptors identified EP4 as the primary mediator of PGE2-induced bone formation [10]. While the role of EP1 in osteoblastic differentiation and bone metabol

• br Restenosis after angioplasty remains a

  2019-11-27

  

  Restenosis after angioplasty remains a remarkable challenge, although drug-eluting stents have reduced the incidence of restenosis considerably . Vascular smooth muscle N6-Methyl-dATP (VSMCs) play a pivotal role in the development of intimal thickening and restenosis. VSMCs proliferate and migrat

• DNA hypomethylation has been found in liver tumor and

  2019-11-27

  

  DNA hypomethylation has been found in liver tumor and other tumors of humans, such as laryngeal cancer, Formoterol Hemifumarate sale tumors, tongue squamous cell carcinoma and uterine leiomyomas [[20], [21], [22], [23], [24]]. Then, we mainly sought to confirm whether TCA could induce DNA hypomethy

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