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Data were collected using a
2021-12-16
Data were collected using a Powerlab and Chart 5 software (ADInstruments, Bella Vista, NSW, Australia) and were analysed using GraphPad Prism 5 (GraphPad Software, San Diego, CA). Responses to ghrelin receptor agonists in phenylephrine, methoxamine, endothelin-1, U46619 and 60mM [K+] contracted vess
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In conclusion starting from the weakly potent
2021-12-16
In conclusion, starting from the weakly potent GSM , exploration of various spacer groups between the triazole ring and the aromatic Asiaticoside led to the discovery of a new series of potent gamma secretase modulators, with an improved drug-like profile—compared with the originally reported serie
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We and others have previously reported that neurons generate
2021-12-16
We and others have previously reported that neurons generated from iPSCs with genetic forms of AD recapitulate aspects of the disease, including increased Aβ peptide production in trisomy 21 and APP duplication neurons (Moore et al., 2015, Israel et al., 2012) and increased production of longer form
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Main Text FFAR GPR is a
2021-12-15
Main Text FFAR1 (GPR40) is a long-chain fatty salubrinal (LCFA) receptor highly expressed and enriched in enteroendocrine cells, where it senses LCFAs generated from dietary triglycerides, and in pancreatic islet cells, where it acts as a powerful stimulator of insulin secretion. However, the phys
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Erythropoiesis involves the proliferation and differentiatio
2021-12-15
Erythropoiesis involves the proliferation and differentiation of hematopoietic stem loteprednol etabonate synthesis to mature RBCs. This process is a tightly-regulated to adjust rates of RBC production based on physiologic need. Fas-mediated apoptosis is one mechanism that controls erythropoiesis.
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Main Text There are over small
2021-12-15
Main Text There are over 200 small GTPases that play critical roles in diverse fundamental cellular processes such as signal transduction, Vincristine mg dynamics, and intracellular trafficking. Most of the GTPases act as switch-like molecules by cycling between the guanosine triphosphate (GTP)-bo
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br Acknowledgements br Introduction Type diabetes is a progr
2021-12-15
Acknowledgements Introduction Type 2 diabetes is a progressive metabolic disorder which is characterised by chronic hyperglycaemia due to relative insulin deficiency, insulin resistance and increased hepatic glucose production [1]. The metabolism of glucose by glycolysis increases the ATP:ADP
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In the present study we conducted
2021-12-15
In the present study, we conducted a search for other possible endogenous ligands for GPR35. We focused on lysophospholipids because of the homology (30%) between GPR35 and GPR55 whose endogenous ligand is lysophosphatidylinositol (LPI) [9], especially 2-arachidonoyl LPI [10]. Notably, the GPR35 gen
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br Materials and methods br Results br Discussion In this
2021-12-15
Materials and methods Results Discussion In this study, the supF forward mutation assay showed that 5OHU induced mutations in human cells and that a C→T mutation was the predominant mutation among 5OHU-induced mutations. In addition, the DNA cleavage activity assay revealed that 5OHU was ex
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Our results indicate that abcb
2021-12-15
Our results indicate that abcb5 is likely to be a XT in zebrafish ionocytes, although, like renal cells, the phenotypes observed likely arise from the action of multiple transporters. Zebrafish lack an abcb1 ortholog, and abcb4 and abcb5 have been identified as the P-glycoproteins in zebrafish (Fisc
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The ester moiety is a promising structural motif at the
2021-12-15
The ester moiety is a promising structural motif at the C-3 position for the development of drug-like molecules. However, the labile C-3 ester bond impels these derivate to be susceptible to plasmatic degradation by esterases and this is natural steroidal metabolic process [39,40]. Hence, the isoste
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Our data suggest that Slc
2021-12-15
Our data suggest that Slc38a5 is important for amino-acid-induced α cell proliferation and expansion of α cell mass following GCGR inhibition, but not for formation and maintenance of α cell mass. This is supported by the finding that Slc38a5−/− mice have normal α cell mass. This is interesting sinc
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Interruption of glucagon signaling pathway targeting glucago
2021-12-15
Interruption of glucagon signaling pathway targeting glucagon receptor (GCGR) by gene knockout, antisense oligonucleotides or specific antagonists induces α-cell hyperplasia and alleviates hyperglycemia and other metabolic symptoms in diabetic animals and patients [[7], [8], [9]]. Here we used a ful
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br Conclusion and future directions
2021-12-15
Conclusion and future directions GS is an important therapeutic target for the treatment of Alzheimer's disease. Its structure and function have been studied during the last years to understand the substrate cleavage mechanism to modulate the Aβ42 peptide production. The recent elucidation of GS
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Seizures in turn selectively modulate the expression of GalR
2021-12-15
Seizures, in turn, selectively modulate the VX-745 of GalR in the hippocampus. Thus, pilocarpine-induced SE led to a 30% downregulation of GalR2 without affecting GalR1 (personal communication with T. Bartfai, Scripps Research Institute). Therefore, despite the fact that GalR2 could have been a mor
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