• APJ receptor expression is altered in various cardiovascular

  2024-07-31

  

  APJ receptor expression is altered in various cardiovascular diseases, and both increases as well as decreases in APJ receptor expression have been reported. A decrease in mRNA and protein levels of APJ receptors was observed in patients with ischemic heart disease or idiopathic dilated cardiomyopat

• Cells have developed strategies aiming

  2024-07-30

  

  Cells have developed strategies aiming to enhance both the efficiency of proteins with chaperone activity as well as their overall antioxidant capacity to maintain proteostasis under oxidative stress conditions (Miyata et al., 2012). For instance, 2-Cys peroxiredoxin is an abundantly expressed, anti

• Blockers will reduce perioperative myocardial

  2024-07-30

  

  β-Blockers will reduce perioperative myocardial ischemia and studies published in the 1990s suggested that their routine administration before surgery provided protection against perioperative CV complications.31., 32., 33. Based on these early studies, several national organizations endorsed the pe

• Introduction Adenosine kinase ADK ATP adenosine phosphotrans

  2024-07-30

  

  Introduction Adenosine kinase (ADK; ATP: adenosine 5′-phosphotransferase, EC 2.7.1.20), is isolated from yeast cells by Kornberg for the first time in 1951 [1]. ADK belongs to the ribokinase protein family and is one of the most abundant nucleoside kinases in mammalian tissues [2,3]. As the first i

• Introduction Myasthenia gravis MG is an autoimmune disorder

  2024-07-30

  

  Introduction Myasthenia gravis (MG) is an autoimmune disorder characterized by muscle weakness, which is mainly due to autoantibodies reducing the number or function of postsynaptic citric acid receptor receptors (AChRs) [1], [2]. Animal models have been developed to uncover the immunopathogenesis

• The extent to which GPCR oligomerization is a regulated proc

  2024-07-30

  

  The extent to which GPCR oligomerization is a regulated process still remains unclear. Reported effects of ligands on both GPCR homo- and heteromers are highly variable and depend on GPCR subtypes and the specific ligand used. According to our data, chronic treatment of mice with both paroxetine or

• Autotaxin has been linked to

  2024-07-30

  

  Autotaxin has been linked to chemoresistance through its ability to inhibit apoptosis induced by paclitaxel in breast cancer MAPK Inhibitor Library mg [15] and LPA can inhibit cell death induced by cisplatin [40]. Autotaxin was included in the present study because it was identified as being over-e

• br Materials and methods br Results br Discussion Numerous

  2024-07-30

  

  Materials and methods Results Discussion Numerous studies showed that Na+-K+-ATPase activity and membrane sirreal were decreased in cardiac tissue subjected to IR (Belliard et al., 2013; Lee et al., 2013). In return, treatment that alleviated the progress of IR-related myocardial injury is

• The uterine muscle also changes to

  2024-07-30

  

  The uterine muscle also changes to meet the demands of pregnancy. Over the course of pregnancy, the myometrium undergoes structural remodeling to accommodate a growing fetus, followed by a functional switch from quiescent to contractile characteristics for parturition. Studies on the mouse model ind

• Molecular simulation has proven useful

  2024-07-30

  

  Molecular simulation has proven useful in describing the dynamics and energetics of NMDA receptor LBD cleft closure and the potentiating role of glycans (Yao et al., 2013, Dai and Zhou, 2013, Dai and Zhou, 2015, Dai and Zhou, 2016, Dutta et al., 2015, Omotuyi and Ueda, 2015, Sinitskiy and Pande, 201

• br Acknowledgements This work was supported by the Victorian

  2024-07-30

  

  Acknowledgements This work was supported by the Victorian Government Operational Infrastructure Support Program. KAB is supported by the Mavis Robertson Fellowship from the National Breast Cancer Foundation (NBCF; ECF-16-004), by an NBCF Novel Concept Award (NC-14-011), and by NHMRC project grant

• Autophagy and apoptosis have a very complex relationship and

  2024-07-30

  

  Autophagy and apoptosis have a very complex relationship, and the precise mechanism remains to be determined. At present, a large amount of research has confirmed that autophagy can protect the cell from apoptosis in special conditions such as nutrient deficiency or growth factors deprivation; the e

• br Introduction The term antioxidant derives from

  2024-07-30

  

  Introduction The term antioxidant derives from the prevention of the oxygen consumption. In the late of 19th centuries, antioxidants were generally used in industrial processes such as against to metal corrosion, vulcanization of rubber. Later on, the use of antioxidants to prevent the rancidity

• Methods We conducted a secondary analysis

  2024-07-29

  

  Methods We conducted a secondary analysis of an extant cohort of 580 infants and survival free of NEC in the first week of life. One patient was excluded because of unknown maternal antibiotic status. Data collection followed the protocol of the Eunice Kennedy Shriver National Institute of Child H

• A Belgian review on perioperative management of drugs recomm

  2024-07-29

  

  A Belgian review [9] (2011) on perioperative management of drugs recommends not using ACEI/ARBs due to the same reason. Another 2014 French [10] publication on the management of antihypertensive drugs in the perioperative period suggests withholding this medication before surgery even though they a

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