• br Author contribution br Acknowledgement br Introduction

  2022-11-01

  

  Author contribution Acknowledgement Introduction Since the initial finding of Gould et al. [1], showing the loss of dendritic spines in the hippocampus after ovariectomy and its rescue after treatment of the animals with estradiol, a tremendous number of studies have demonstrated a role of

• SAR405 mg br Material and methods br Results br Discussion T

  2022-11-01

  

  Material and methods Results Discussion The present study demonstrates for the first time that Mino selectively induces apoptosis in Jurkat SAR405 mg via an H2O2 signaling-dependent mechanism. Structurally, Mino is composed of a C10 and C12 phenol group, C12a hydroxyl group, and C1 and C11

• Although the earlier studies focused

  2022-11-01

  

  Although the earlier studies focused on the antioxidant capacity of tocopherols, ascorbic pp2 and carotenoids, then it was noticed that phenolic compounds were more powerful than others (Rice-Evans, Miller, & Paganga, 1996). Phenolic compounds, the most numerous and ubiquitous groups of plant second

• Modulating the ability of tumor cells

  2022-10-31

  

  Modulating the ability of tumor Patchouli alcohol to detoxify ROS is a key mechanism by which cysteine metabolism affects tumor cell survival. One study observed hypermethylation of cysteine dioxygenase (CDO1) in 60% of tested breast cancer samples, leading to increased ROS detoxification and tumor

• phospholipase inhibitor In silico docking analysis performed

  2022-10-31

  

  In silico docking analysis performed in the current study indicated that TCDD strongly binds to AhR-LBD. Moreover, the formation of the TCDD/AhR-LBD complex was confirmed experimentally with the use of EMSA. We found that 10nM TCDD after 2 hours of incubation not only bound to the AhR in the porcine

• AdipoR and AdipoR have been reported to

  2022-10-31

  

  AdipoR1 and AdipoR2 have been reported to be present in almost all type of tissues and low Raltitrexed levels have been observed in white adipose tissue (Inukai et al., 2005). These receptors have been observed to become deregulated with the onset of obesity, resulting in a reduced level of APN exp

• The activation of P Rs modulates the activity of many

  2022-10-31

  

  The activation of P1Rs modulates the activity of many ion channels and receptors (Sebastião and Ribeiro, 2009) and the recent detection of P1Rs at the postsynaptic level of the adult NMJ (Garcia et al., 2014) makes potentially possible an adenosine-mediated modulation of the nicotinic I-BET151 rece

• The total IgG concentration decreased from

  2022-10-31

  

  The total IgG concentration decreased from a mean of 997 mg/100 ml before treatment to a mean of 696 after treatment in the MuSK+MG patients, and from a mean of 1736 mg/100 ml to a mean of 802 mg/100 ml in the AChR+MG patients (normal values 723–1685 mg/100 ml). This decrement was also statistically

• Introduction Cancer which is responsible for a

  2022-10-31

  

  Introduction Cancer, which is responsible for a million deaths each year, is universally feared, and approximately 50% of newly diagnosed cases can be cured [1]. The existing cancer treatments, including surgery, chemotherapy, radiotherapy or a combination of them, are quickly losing efficacy. The

• The ATX LPA signaling axis has been implicated in

  2022-10-31

  

  The ATX–LPA signaling “axis” [5] has been implicated in a perplexing variety of physiological and pathophysiological processes, including vascular and neural development [5], [26], [27], [28], [29], tumor progression and metastasis [30], [31], lymphocyte trafficking [22], bone development [32], neur

• Over the past decade extensive research has been

  2022-10-31

  

  Over the past decade, extensive research has been directed toward the discovery of Aurora-selective small-molecule inhibitors. As a result, a handful of Aurora inhibitors has been identified. Among them, 1 (VX-680) and 2 (SNS-314) have entered human clinical trials as pan-Aurora kinase inhibitors (F

• br Apelin The APJ receptor ligand apelin firstly in was

  2022-10-31

  

  Apelin The APJ receptor ligand apelin firstly in 1998 was segregated from bovine stomach tissue. Human preproapelin gene located on chromosome Xq25–26.1. The apelin preproproteins consist of 77 amino Cy5 hydrazide (non-sulfonated) residues that are cleaved into biologically active C-terminal fra

• br STAR Methods br AMPK

  2022-10-28

  

  STAR★Methods AMPK: A Therapeutic Target in the β Cell? Loss of pancreatic β cell function is a hallmark of the transition to a diagnosis of T2DM (see Glossary) 1, 2, 3, 4. AMPK activation has gained attention for the treatment of hyperglycemia in prediabetes as an insulin-sensitizing agent bec

• Asparagine synthetase ASNS is a glutamine

  2022-10-27

  

  Asparagine synthetase (ASNS) is a glutamine amidotransferase that catalyzes ATP-dependent synthesis of asparagine and glutamate from aspartate and glutamine. Upregulation of ASNS expression renders leukemia cells resistant to l-asparaginase treatment, and ASNS is essential for cell survival in the a

• Di ethylhexyl phthalate DEHP is one

  2022-10-27

  

  Di-(2-ethylhexyl) phthalate (DEHP) is one of the most widely used environmental chemicals in the production of polyvinyl chloride. After Eosin Y into human body, DEHP can be converted to the metabolite mono-ethylhexyl phthalate (MEHP), which has higher toxicity than DEHP and can influence reproduct

14248 records 353/950 page Previous Next First page 上5页 351352353354355 下5页 Last page