• Despite hydrolysis with commercial enzymes

  2024-12-17

  

  Despite hydrolysis with commercial enzymes like trypsin, pepsin, Alcalase, Flavourzyme and Thermolysin have been used to digest parent proteins and generate peptides, microbial fermentation by proteolytic species has also proved to be a successful strategy (Fakhfakh et al., 2013, Jemil et al., 2016,

• Casein accounts for of the total protein in bovine

  2024-12-17

  

  Casein accounts for 80% of the total protein in bovine milk (Capriotti, Cavaliere, Piovesana, Samperi, & Laganà, 2016); hydrolysates or bioactive peptides derived from casein have been employed widely in food as a functional ingredient (Capriotti et al., 2016, Field et al., 2008). Many studies have

• br Conclusion In this brief Letter we report

  2024-12-17

  

  Conclusion In this brief Letter, we report an easy method for the preparation of the antileukemic natural product 1. Using a biomimetic strategy,1, 8 in which the aromatic residues are attached to a lysine moiety prior to the reduction of the central carboxylate group, a step-economical synthesis

• We have recently reported a regulatory effect

  2024-12-16

  

  We have recently reported a regulatory effect of quercetin on the AChE activity in the brainstem during the demyelination and remyelination process [17]. It has also been observed that there is a protective effect on lipid peroxidation and worsening of motor functions caused by loss of myelin in the

• br Conclusion br Acknowledgements br Introduction Synapses

  2024-12-16

  

  Conclusion Acknowledgements Introduction Synapses are the fundamental elements of neuronal networks that enable the processing, encoding, and retrieval of information in the brain, and pathological disruptions in synapse structure are broadly held to underlie the development of neurological

• Because R gene is positively regulated by T and in

  2024-12-16

  

  Because 5α-R2 gene is positively regulated by T and in the prostate gland (Torres et al., 2003), and our BPA-treated rats showed decreased circulating T and probably intraprostatic androgen levels, it might be responsible for the decrease of 5α-R2 expression. However, in a previous work using castra

• The mitochondrial protein AIF was the first caspase independ

  2024-12-16

  

  The mitochondrial protein AIF was the first caspase-independent death effector. AIF can induce caspase-independent chromatin condensation and large-scale DNA fragmentation to approximately 50 KB. AIF that is released to cytoplasm can mediate apoptosis when special extracellular signals trigger the o

• br HMG proteins mobile modulators of

  2024-12-16

  

  HMG proteins: mobile modulators of chromatin structure and cellular phenotype The term “High Mobility Group” was originally coined for the HMG proteins because of their unusual solubility properties, their small size and their rapid mobility, relative to other chromatin proteins, during gel elect

• Immunohistochemistry in tissue samples showed the

  2024-12-16

  

  Immunohistochemistry in tissue samples showed the expression of several nuclear receptor co-activators, including NCOA1, NCOA2, NCOA3, CREBBP, and EP300, in 85–100% of sodium fluoride receptor tumors even some of which lacked AR expression (Boorjian et al., 2009). Knockdown of each co-activator al

• The diversity of metabolic adaptations employed

  2024-12-16

  

  The diversity of metabolic adaptations employed by cancer cells in response to rapidly changing conditions, contributes to their biological aggressiveness and therapeutic resistance by enabling them to proliferate when nutrients are plentiful and to shift their resources to survival when nutrients a

• Within the PARP family TIPARP is

  2024-12-16

  

  Within the PARP family, TIPARP is most evolutionarily conserved with PARP12 (ARTD12) and PARP13 (ARTD13) [27,28,41]. All three proteins contain at least one RNA-type CCCH zinc finger domain, a poly-ADP-ribose binding WWE domain and a PARP catalytic domain (Fig. 1). PARP13 is catalytically inactive,

• In conclusion we have shown that mGlu

  2024-12-16

  

  In conclusion, we have shown that mGlu7 receptors negatively regulate α1-adrenergic receptor signalling in heterologous expression systems, Tanshinone I tissue and living animals. This interaction might represent a protective mechanism aimed at restraining an excessive activation of noradrenergic t

• 5153 synthesis Tension within the network could

  2024-12-16

  

  Tension within the network could be explained by two potential mechanisms: the more classical contractility that is dependent on motor proteins that are pulling 5153 synthesis filaments towards each other [10]; or contractility that is caused by disassembly of a crosslinked network of actin filamen

• br Introduction Myasthenia gravis MG is an autoimmune diseas

  2024-12-13

  

  Introduction Myasthenia gravis (MG) is an autoimmune disease in which antibodies against targets on the postsynaptic muscle membrane cause neuromuscular transmission failure. About 85% of patients with MG have autoantibodies against renin inhibitor receptor (AChR) [1]. In AChR negative MG patient

• pdk 1 br AChE variants and their functions The

  2024-12-13

  

  AChE variants and their functions The AChE gene generates several splice variants of AChE which are designated as hydrophobic (H), readthrough (R) and tailed (T) forms differing in membrane association and also localisation on a tissue and sub-cellular level. They all undergo significant posttran

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