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br Conflict of interest br Acknowledgements This work was su
2019-10-04
Conflict of interest Acknowledgements This work was supported in part by JSPS KAKENHI Grant Number 26292031. We thank Nissan Chemical Industries, Ltd. for the gift of the sample of fluralaner. Introduction As one of the most common cancers in southern China and southeast Asia, nasopharynge
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br Introduction The development of non melanoma skin
2019-10-04
Introduction The development of non-melanoma skin cancer (NMSC) is a complex process characterized by the acquisition of altered proliferation and invasiveness. These changes are classically defined as occurring in stages, i.e., initiation, promotion, and progression. In the two-stage model of in
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br Introduction Biocatalysis can be used to synthesize chira
2019-10-03
Introduction Biocatalysis can be used to synthesize chiral building blocks, such as monomers for polymer materials, and precursors for pharmaceuticals [[1], [2], [3], [4]]. Enzymes are very suitable for catalyzing reactions with high enantioselectivity to obtain chiral products. For instance, alc
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br STAR Methods br Acknowledgments We would like to
2019-10-02
STAR★Methods Acknowledgments We would like to thank Dr. Tsung-Ping and Dr. Shang-Yi Tsai, National Institute on Drug Abuse, NIH for sharing protocols on pulse chase experiments and analysis. We would like to thank Dr. William G. Telford for his valuable input on Amnis flow cytometry experiment
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br Material and methods br
2019-10-02
Material and methods Results Discussion A. fumigatus utilizes several virulence factors that facilitate its establishment in human hosts. Among these factors, the best known are hydrolytic enzymes such as proteases and phospholipases, toxins, melanine and catalases that neutralize the react
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br Introduction Epithelial mesenchymal transition EMT is a b
2019-10-02
Introduction Epithelial-mesenchymal transition (EMT) is a biological process by which epithelial 94 6 mass lose cell polarity and cell-cell adhesion, and gain mesenchymal features with an increase of migratory and invasive properties [1]. EMT is essential for mesoderm formation during embryo dev
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Our results indicate an OT specific
2019-10-02
Our results indicate an OT-specific activation of PKR that inactivates eIF2a and may, by this means, reduce protein translation by utilizing only select sensors and mediators of the UPR (i.e., avoiding significant PERK activation). Interferon is a PKR activator [32] that temporarily subdues cellular
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br Materials and methods br Results br
2019-10-02
Materials and methods Results Discussion Macrophages and dendritic cells respond to Toll-like receptor (TLR) ligands by upregulating CH25H expression [4], [5]. In the latter cell type TLR-dependent upregulation is mediated via a signalling pathway that involves NFκB and IFNβ secretion and c
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CXCR is not only critical in the B cell
2019-10-02
CXCR5 is not only critical in the B cell lineage in FL. A high proportion of CXCR5-expressing follicular helper T cells (TFH) were observed in FL but not in closely related DLBCL [141] and further investigation revealed that FL regulatory T cells (Tregs) used a CXCL13-CXCR5 autocrine loop for positi
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Covalent inhibitors are well suited for targeting the E enzy
2019-10-02
Covalent inhibitors are well suited for targeting the E1 TCS 2510 mass of Ubl modifications. Because the E1 enzymes in Ubl modifications, such as the SUMO E1 and Atg7, have a slow turnover rate (Boggio et al., 2004), prolonged inhibition can be achieved without requiring compounds to be stable in ci
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br Introduction Plasmodium falciparum malaria continues to b
2019-10-02
Introduction Plasmodium falciparum malaria continues to be a major global cause of mortality and morbidity. Malaria treatment and control has been complicated by the emergence of resistance to widespread antimalarial drug use. The most common method for measuring antimalarial resistance is estima
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Dexamethasone DEX a potent synthetic glucocorticoid drug is
2019-10-02
Dexamethasone (DEX), a potent synthetic glucocorticoid drug, is effective for treatment of a range of inflammatory and autoimmune conditions as well as the reduction of side effects associated with chemotherapy. On the Czech Republic pharmaceutical market, DEX is incorporated into eighteen drugs use
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It is well known that the tumor suppressor p
2019-10-02
It is well known that the tumor suppressor p53 plays an important role in regulating the CVT 10216 and cellular senescence [43,46,48]. For example, FOXO4 could interact with P53, which selectively induced apoptosis in senescent cells [48]. In addition, loss of MECP2 was found to lead to the inductio
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br Acknowledgment S A was supported by
2019-10-02
Acknowledgment S.A was supported by V Plan Propio US-AccesoUSE-14793-G. Introduction Neutrophils are innate immune sirreal and of primary importance for protecting against infections by microorganisms [1,2] through various antimicrobial abilities, including microorganism phagocytosis and ant
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With regards to translational development of SMEPT we
2019-10-02
With regards to translational development of SMEPT, we acknowledge that we are not aware of any trials currently underway to validate this methodology in clinical settings. It appears fair to say that enthusiasm and commitment from corporate developers does not match that of academic partners. One r
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