Studies have focused on a hydrophobic cage at the CULT

2019-08-19

Studies have focused on a hydrophobic cage at the CULT domain, conserved from bacteria to mammals, as it binds to substrates and IMiDs (Chamberlain et al., 2014, Lupas et al., 2015).

E mediated E discharge E

2019-08-17

E3-mediated E2 discharge E3 ligases simultaneously interact with the substrate and the SUMOD charged E2 enzyme to catalyze the discharge of the thioester-bound SUMOD from the E2 to the substrate.

Methods Results Discussion The findings of

2019-08-16

Methods Results Discussion The findings of this study indicate that an ET system including ET-1 and ET-2 as well as ET receptors are present in the retina and RPE/choroid, and are up-regulated by both hypertension and diabetes.

Introduction The cys loop ligand gated ion

2019-08-15

Introduction The cys-loop ligand gated ion channels (LGICs) are membrane-bound proteins mediating fast transduction from chemical to electrical signals at neuronal synapses and neuromuscular junctions [1], [2].

Proinflammatory cytokines induce ER stress in many mammalian

2019-08-14

Proinflammatory cytokines induce ER stress in many mammalian cell systems.32, 33, 34 Our results demonstrate that these cytokines also trigger ER stress in trophoblast JEG-3 cells.

Despite the weak and transient nature of E E interactions

2019-08-13

Despite the weak and transient nature of E2–E3 interactions, this binding is required for the transfer of ubiquitin to the substrate.

Hello world!

2018-07-29