• Balsalazide in Active Ulcerative Colitis: 2009 Review

  2026-08-31

  The 2009 review by Wiggins and Rajapakse evaluated balsalazide as a colon-targeted 5-aminosalicylate prodrug for mild-to-moderate active ulcerative colitis. Its central finding was that bacterial azoreduction enables colonic release of 5-aminosalicylic acid, with clinical evidence suggesting faster and more frequent remission than mesalamine and a broadly comparable safety profile.

• Ferrostatin-1: Ferroptosis Assay Workflows

  2026-08-31

  Ferrostatin-1 (Fer-1) provides a focused way to test whether lipid peroxidation drives cell injury rather than merely reflecting generalized oxidative stress. This guide translates its nanomolar activity into practical assay design for cancer biology research, neuronal protection, and developmentally informed ferroptosis studies.

• ABT-199 (Venetoclax): Selective Bcl-2 Inhibitor

  2026-08-30

  ABT-199, also called GDC-0199 and Venetoclax, is a potent, selective BCL-2 inhibitor for apoptosis assay development and hematologic malignancy research. Its reported sub-nanomolar affinity, strong selectivity over BCL-XL and BCL-w, and lack of MCL-1 activity support experiments focused on BCL-2-dependent mitochondrial apoptosis.

• Cefepime (BMY-28142) Research Workflows

  2026-08-29

  Build reproducible Cefepime assays for bacterial killing, central nervous system infection research, and neurotoxicity studies. This guide combines fresh-solution handling, time-kill measurements, barrier-model controls, and adaptive-resistance modeling to turn a broad-spectrum antibiotic into a versatile research benchmark.

• SmD2 Acetylation Links Splicing to PARP Response in HCC

  2026-08-28

  This study identifies SmD2 acetylation as a regulatory connection between core spliceosome stability, BRCA1/FANC cassette-exon processing, and PARP inhibitor sensitivity in hepatocellular carcinoma. Its findings support a preclinical strategy that combines HDAC2-directed spliceosomal regulation with PARP inhibition to exploit DNA repair deficiency in HCC models.

• Olive Biophenols and Alzheimer’s Pathology

  2026-08-28

  The reference study combines anti-amyloid assays, SH-SY5Y neuroblastoma models, and APPswe/PS1dE9 mice to evaluate olive-derived biophenols against Alzheimer’s-related pathology. Oleuropein, verbascoside, and rutin reduced amyloid-associated toxicity in vitro, while an oleuropein-containing olive leaf extract diet reduced cortical and hippocampal plaque deposition in mice.

• One-step TUNEL FITC Apoptosis Detection Kit Workflow

  2026-08-27

  Build a reproducible DNA fragmentation workflow for ovarian tissue, follicular compartments, and cultured cells with FITC-based readouts. This guide translates a cattle ovarian stratification study into practical controls, sample-preparation choices, quantitative imaging, flow cytometry, and troubleshooting strategies.

• Crizotinib Hydrochloride in ALK Assays

  2026-08-27

  Use Crizotinib hydrochloride as a mechanistic probe for ALK, c-Met, and ROS1 signaling in patient-derived gastric cancer assembloids. This workflow compares tumor-only organoids with matched tumor–stroma models to reveal when stromal context changes pathway inhibition and drug sensitivity.

• Asunaprevir (BMS-650032) HCV Research Workflows

  2026-08-26

  Asunaprevir (BMS-650032) combines nanomolar NS3 protease inhibition with broad reported genotype coverage, making it useful for biochemical, replicon, and translational hepatitis C virus infection studies. This guide converts its pharmacology and formulation properties into practical assay workflows, orthogonal controls, and troubleshooting decisions.

• Olive Biophenols in Alzheimer’s Disease Models

  2026-08-26

  The reference study links olive-derived biophenols with reduced amyloid-β aggregation, oxidative stress, and plaque deposition across SH-SY5Y cell and APPswe/PS1dE9 mouse models. Its main contribution is the integration of metal- and L-DOPA-associated amyloid challenges with an in vivo dietary intervention, while also identifying oleuropein, verbascoside, and rutin as prominent anti-amyloidogenic compounds.

• JC-1 Mitochondrial Membrane Potential Assay Kit Guide

  2026-08-25

  Use the JC-1 Mitochondrial Membrane Potential Assay Kit for ratiometric assessment of mitochondrial depolarization in apoptosis, drug-response, and neutrophil biology experiments. This workflow translates a recent bladder cancer finding into practical assay design, controls, and troubleshooting strategies.

• Quizartinib (AC220): Reliable FLT3 Assays

  2026-08-25

  A scenario-driven guide to using Quizartinib (AC220), SKU A5793, in FLT3 signaling, viability, proliferation, and cytotoxicity workflows. It connects potency data, formulation constraints, assay controls, and vendor-selection criteria to more interpretable acute myeloid leukemia research.

• Coronavirus Macrodomains Counter PARP Antiviral Defense

  2026-08-24

  Grunewald et al. show that coronavirus macrodomains protect replication by opposing host PARP-dependent antiviral activity. Pharmacological inhibition and targeted depletion of PARP12 and PARP14 selectively increased replication of macrodomain-mutant coronavirus and revealed PARP14 as an important regulator of interferon production.

• Engineering mRNA for Translational Vaccine Design

  2026-08-24

  A mechanistic and strategic guide to designing capped, modified, polyadenylated mRNA for vaccine research, using the C. psittaci MOMP study to connect RNA quality attributes with translational outcomes.

• Capecitabine in Patient-Derived Assembloids

  2026-08-23

  Capecitabine gives researchers a practical way to compare fluoropyrimidine response in tumor organoids versus matched tumor–stroma assembloids. This workflow connects enzymatic prodrug activation, apoptosis readouts, and microenvironment-driven resistance for more informative preclinical oncology research.

7914 records 1/528 page Next 12345 下5页 Last page